Products
ERAB antibody
- Product Name
- ERAB antibody
- Catalogue No.
- FNab02823
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- hydroxysteroid(17-beta) dehydrogenase 10
- Alternative Names
- 17 beta HSD 10 antibody, 17b HSD10 antibody, ABAD antibody, CAMR antibody, DUPXp11.22 antibody, ERAB antibody, HADH2 antibody, HCD2 antibody, HSD17B10 antibody, MHBD antibody, MRPP2 antibody, MRX17 antibody, MRX31 antibody, MRXS10 antibody, SCHAD antibody, SDR5C1 antibody, Type II HADH antibody, XH98G2 antibody
- UniProt ID
- Q99714
- Observed MW
- 27 kDa
Application
- Tested Applications
- ELISA, WB, IHC, FC, IP
- Recommended dilution
- WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab02823(HSD17B10 antibody) at dilution of 1:1000
IP Result of anti-ERAB (IP:FNab02823, 4ug; Detection:FNab02823 1:500) with HeLa cells lysate 1200ug.
Immunohistochemistry of paraffin-embedded human breast cancer using FNab02823(HSD17B10 antibody) at dilution of 1:100
- Background
- Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease(AD).
